PHAR 303 Lecture Notes - Lecture 13: Chronic Toxicity, Axoplasmic Transport, Autism Spectrum
15 Feb 2018
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In ancient greece, executions were done through poisoning this is what happened with. Socrates: socrates drank hemlock this is a cns toxin. A majority of naturally produced toxins are neurotoxins: these can act very quickly other organs systems will take a more time to be damaged, but nervous system damage can cause rapid death. We don"t know much about most neurotoxins that are present in nature and that we have synthesized. We use various animal models to study this toxicity. Neurons can be grown in culture to examine the effect of toxicants: they can be grown in wells and then allowed to start communicating with each other. Can allow us to look at synaptogenesis, cell to cell communication, etc. in isolated systems. You can do nerve outgrowth assays plate them and let them grow to observe the effects of toxicants on neural growth.
