PHAR 505 Lecture Notes - Lecture 7: Hydrogen Bond, Fluorophore, Escherichia Coli
12 Oct 2017
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Overview: drug discovery strategies, structure-based lead discovery and optimization, example: hiv protease inhibitors, how to write an abstract. The shaded box emphasises where structure-based methods can play a significant role. The horizontal axis only approximately scales to time in each stage. This figure was taken from the required reading for today. Once this is complete, you will need to focus on lead optimization: potency and specificity of targets. You identify a target first, once you have it then you start looking for small molecules or anything that will hit the target. Optimize the hits then move onto clinical trials. You identify the disease phenotype that you"re interested in, then you have to start looking for small molecules or anything that will affect the phenotype without knowing what the target will be. Then you will do lead optimization and move onto clinical trials.
