PHAR 562 Lecture Notes - Lecture 12: Spasm, Depolarization, Catecholamine
2 Nov 2017
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Details about ach: synthesis + release. Cholinergic receptor subtypes and locations: nicotinic receptors, muscarinic receptors. Lots of focus on the pns and less focus on cns. Ad cholinergic system is targeted in this disease: can help to delay sxs. First identified by mr. dale 1914: by extracting liquid from the heart, he could put it on another heart and get it to beat, action on heart tissue. **sounds like a good mcq for the exam! It has to be made: combo of choline + acetyl-coa, comes from good fats in the diet, we won"t be asked for chemical formulae. Ach pharmacology action: dale 1914, discovered 2 types of activity, muscarinic = machr, nicotinic = nachr. Both nachr and machr occur pre and postsynaptically and function to regulate transmitter release. One of the transmitters in the ans: the only nt in the somatic ns. **good mcq: pns that acts as a control system maintaining a homeostasis in the body.
