PHAR 562 Lecture Notes - Lecture 20: Neuropathic Pain, Chronic Pain, Trigeminal Nerve Nuclei
13 Nov 2017
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Document Summary
From periphery to cns: primary sensory neurons and local anesthetics, peripheral sensitization, nsaids, ngf and trpv1, spinal cord and opioid receptors, neuropathic pain and non-nsaid, non-opioid drugs, supraspinal pain processing and neuroplasticity. Interpersonal & financial stress, loss of identity & self- worth, sleep and chronic fatigue. Inability to work leads to increased stress: too much stress then can"t sleep and it is a vicious cycle. If you injure your leg, you will have decreased sensitivity in other areas as well: can be tested in lab, fibromyalgia: normally, normal every day aches and pains are dampened down by regulatory systems. Sensory transduction: thermal, mechanical, ph, chemical: types of receptors, trpv1: capsaicin receptor. Just in the temperature range where you start to feel pain, that"s the exact temperature where the receptor turns on. There is a very fine overlap/synchronization between sensation & transduction: trek-1.
