PHAR 562 Lecture Notes - Lecture 16: Chronic Obstructive Pulmonary Disease, Neuropathic Pain, Chronic Pain
12 Feb 2020
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What makes a good analgesic drug: analgesic efficacy, long acting for chronic conditions, minimize undesirable effects, easy to administer (preferably good oral bioavailability, minimize abuse potential. From periphery to cns: primary sensory neurons & local anesthetics, peripheral sensitization, nsaids, ngf, spinal cord and opioid receptors, neuropathic pain and non-nsaid, non-opioid drugs, supraspinal pain processing, neuroplasticity, epigenetics. We are bad at treating pain; there aren"t many good drugs! Prolonged pain during inflammation/repair after injury: normal and protective, designed to. Acute vs. chronic pain punish movement and promote recovery. Chronic pain: can be protective & non-protective. Osteoarthritis: pain tells you to take care of your joints because they are inflamed. 10% of patients that had nerves pinched during surgery develop chronic pain from and degenerating = protective pain nerve damage = non-protective pain. Developing world: iron-deficiency anemia, developed world: fall-associated damage. Chronic pain: cost to individual: physical: pain, physical disability, functional impairments, but more of concern:
