PHAR 562 Lecture Notes - Lecture 21: Μ-Opioid Receptor, Opioid Receptor, Opioid Peptide
13 Nov 2017
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Inhibition of primary afferent activation: there are opioid receptors in the skin so it is technically possible to have opioid agonist blocking peripheral pain from entering cns. In this experiment they have applied increasing amounts of pressure to the nerve and the response increase. In presence of morphine, dampened response in dose-related manner: wash morphine away the response starts to come back. Imodium, peripherally restricted, does not get into cns: you would have to drink something like 50l to get any kind of high, dry mouth. In reality, most pain conditions are mixed: question is nep always chronic, prof doesn"t think so. Ie. slipped disc can be fixed, when nerve is liberated then the pain will go away. If there is permanent nerve damage then perhaps it will be chronic: types of pain. Inflammatory acute or chronic inflammation: nociceptive direct lesion or injury, neuropathic caused by damage to nervous system, mixed (not one thing or another)
