PHAR 562 Lecture Notes - Lecture 14: Opioid Use Disorder, Pimozide, Morphine
12 Feb 2020
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Is the opposite of tolerance (see last class: over time, the same dose of drug produces a larger effect, demonstrable with cocaine. Study: (done with amphetamines and not cocaine) For example: administer heroin and give the option to self-administer morphine become tolerant to morphine, need a higher dose to mimic heroin. Subjective effects: a lot of people assume the high drives the addictive behaviour, but reality is more complex. Addiction is usually described in terms of pleasure, but is this accurate: many addicts become tolerant and dependent on drugs and may use it to avoid withdrawal, pleasure can be dissociated from reinforcement. For example, opioid addicts experience pain with withdrawal. Reinforcement is repeating the behaviour to take the drug. Give humans capsules with a placebo or one or two doses of methamphetamine. Had to rate the pleasurable high of the capsules: low dose and placebo perform the same, high dose is detected as a high .
