PHAR 562 Lecture Notes - Lecture 22: Amyloid Precursor Protein Secretase, Psen1, Presenilin
12 Feb 2020
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Document Summary
Secretases that are important for the ad pathology. App -ctf (via -secretase) a (via -secretase: -ctf is still in the membrane, a is a free protein. Has many different lengths, the main pathological one is a 42. Oligomerization causes toxic plaque pathology and leads to the rise of pathology. Everyone produces, the problem is when it"s either created too fast or not degraded fast enough current hypothesis: ad is a problem of amyloid clearance. Pathogenesis of all neurodegenerative diseases have in common the aggregation of proteins: -secretase is an enzyme complex, for example, alzheimer"s disease is characterized by amyloid aggregation outside cells and hyperphosphorylated aggregation inside neurons. The amyloid hypothesis is the main hypothesis for ad"s as it is always associated with ad"s, and it may. The fact that fad exists proves that alzheimer"s is a disease and not a normal age-associated. Loss of normal function even be the causative agent. development: fad is caused by mutations in 3 genes:
