PHGY 209 Lecture Notes - Lecture 13: Erythropoiesis, Glycoprotein, Lymphatic System
30 Oct 2016
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Solubilitty of o2 in plasma is very low: 0. 3ml o2/100ml plasma. In blood because of hb carrying capacity is higher (70x higher: 20ml o2/100 ml of blood. Transport o2: combines to form oxyhemoglobin. Why is hb if inside plasma instead of cell: plasma viscosity, plasma c. o. p, loss via kidney (lymph system) When hb saturated, each gram of hb holds 1. 34 ml o2: capacity of blood is 15*1. 32= 20ml o2/100ml blood. Factors affecting ability of hb to bind o2. Last only about 4 months: replaced at 2-3 million / second. Red cell precursors proliferation: divides exponentially from myeloid stem cell over the course of 3-5 days in bone marrow, the stimulus for this is erythropoietin. Does not act on the stem cells. Acts on the committed stem cell: new cells released into circulation. Known as reticulocytes before they can become erythrocyte. Remains of ribosome material still remain inside and can be visualized.
