PHGY 209 Lecture Notes - Lecture 14: Rubisco, Heme, Bile Duct
16 Sep 2016
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Advantages of having hb inside the cell (rather than dissolved in plasma): Female: 14 g/100 ml blood: when hb is fully saturated with o2, each gram of hb holds 1. 34 ml o2. Therefore, the o2 carrying capacity of blood is 15x1. 34 = 20 ml o2/100 ml blood. Factors affecting ability of hb to bind and release o2: temperature. Normal reticulocyte count < 1% (reflects the amount of effective erythropoiesis in bone marrow) Shows network (reticulum) of ribosomal material involved in the production of hemoglobin present for 24 hours for newly released rbc availability. Variations in rbc counts at different altitudes -------------- > A glycoprotein hormone/cytokine produced largely by the kidney. Stimulus for its release is hypoxia (which may result from decreased rbc count, or decreased availability of o2 to blood, or increased tissue demand for o2) It has been purified, sequenced, gene has been cloned, and epo has been produced by recombinant dna technology.
