PHGY 209 Lecture Notes - Lecture 6: Tissue Factor Pathway Inhibitor, Coagulopathy, Tissue Factor

• School: McGill University
• Department: Physiology
• Course: PHGY 209
• Professor: Melissa Vollrath

Document Summary

Also produce nitric oxide which is a vasodilator and an inhibitor of platelet adhesion, activation and aggregation. Platelet plug is the main mechanism used to seal breaks in vessel walls. Transformation of the blood into a solid gel called clot or thrombus. Occurs around the original platelet plug and is the main hemostatic defence. Function: to support and reinforce the platelet plug and to solidify blood that remains in the wound channel. Activations consist of splitting a small peptide fragment from the inactive plasma protein, hence exposing the active site of the enzyme. Prothrombin is converted to thrombin which causes the plasma protein fibrinogen to lose several polypeptides. This fibrinogen then binds to each other to form fibrin. Thrombin causes a large positive feedback effect in its own production. This causes platelets to display specific plasma membrane receptors and display particular phospholipids called platelet factors (pf)