PHGY 210 Lecture Notes - Lecture 3: Lipolysis, Negative Feedback, Adrenocorticotropic Hormone
25 Feb 2013
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Blood clotting and neural excitability, bones, muscle contractions are all dependent upon calcium level. Controlled at 10mg/100ml, 50% free and 50 bound to albumin in the cellular and extracellular fluids. 99% of the calcium in the body is kept in the bone, with the bone serving as a reservoir. Absorbed by the intestine and the kidney, with maintenance of plasma calcium is by the exchange of bone and plasma levels due to hormones. Calcitonin is produced by parafolicular or c cells of the thyroid gland, opposite of the pth. Eaten and absorbed by the duodenum and upper jejunum. Calcitonin increases calcium deposition to the bones or other reservoirs. Drops bellows 10mg/ml, pth leads to reabsorption and conscription of the calcium of the bone calcium. Hormonal influences stabilizes calcium level of the blood. Parathyroid hormones (pth): secreted from chief cells of the parathyroid. 84 aa in total, 34 of the n terminus necessary for recognition by the receptors.
