PHGY 312 Lecture Notes - Lecture 4: Capacitance, Great Vessels, Cytoskeleton
24 May 2016
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Document Summary
Cardiocentric model (levy: concept of arterial pressure driving the flow around the circuit. Circuit model (guyton: there needs to be a compliant region to have flow, compliance, a static parameter, is an important determinant of flow, c=v/p. Bath tub concept: the height of water above the tub determines the outflow!!! Msfp = mean systolic filling pressure = pressure in veins/art upstream (systemic circulatory system) Mcfp = mean circulatory filling pressure = total pressure in circulation. When draining a tub, only the volume above the hole is important! (stressing volume) Only water above the hole can create the msfp. Curvilinear when you get to lower volumes (unstressed volume) Slope = pressure/volume = 1/compliance = elastance, e = p/v. Principle: heart controls co by regulating right atrial pressure, not by controlling. Co is determined by the interception of this cardiac and venous return function. Heart plays a permissive role; lowers the pressure in ra to generate a gradient.
