PHGY 314 Lecture 20: Chacron - lecture 20
11 Feb 2017
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Slices bathed in artificial csf supplemented with oxygen and glucose. Record from ca1 pyramidal cells (they have place fields) Stimulus given to the schaffer collaterals coming from ca3 pyramidal cells. In the expt, a test pulse is given to the schaffer collaterals: Very low freq test pulses given then magnitude of. Next, tetani of different freq were applied and the. 10hz some depression which quickly returned to control levels. Ltd requires moderate nmda activation and moderate ca elevation: more ampars being internalised and fewer rs binding to glutamate. Ltp requires strong nmda activation and high ca elevation: more ampars being placed on the membrane, more rs binding to glutamate. When there is no ca (or no active nmdar), there is no synaptic plasticity. There is a constant tug of war between ltp and ltd driving mechanisms: the relative strength of the mechanism depends on ca concentration in the cell. Nmdars + ca = postsynaptic mechanism of plasticity.
