PSYC 317 Lecture Notes - Lecture 20: Sleep Deprivation, Cholinergic, White Matter
11 May 2016
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Two ways to connect a gene with a trait: linkage mapping: has also been done in humans (but not much). The difference between linkage and association is that linkage requires pedigrees. When we make an f2 hybrid, what we are doing is making a pedigree. In mice, you can make really big pedigrees (not so much in humans). When applied to humans, linkage mapping is an attempt to follow the inheritance of a disease through the pedigree and compare that to the inheritance of an interested dna variance. It can be done with no pedigrees (though there is a form of association studies that is done with pedigrees). Across-pedigree (cid:894)(cid:862)(cid:272)ase-(cid:272)o(cid:374)trol(cid:863)(cid:895) association: without using pedigrees; get a bunch of people with the disease and compare them to a bunch of people without the disease (matching the subjects as well as we can) Looking at frequencies of alleles and not inheritance of alleles (none of the subjects are related to each other)
