PSYC 318 Lecture 19: Neural Circuits Underlying Drug Addiction 2
8 Feb 2017
School
Department
Course
Professor
Document Summary
Lecture 19 neural circuits underlying drug addiction 2. Paper 14 orbitofrontal activation restores insight lost after cocaine use. Insight is used here as a way to describe model-based inferences. It is the ability to mentally simulate or imagine the likely outcomes of one"s behaviour (in which the outcomes have not been directly experienced previously) Insight is measured by how much animals respond during reward-predictive situations that they have not directly encountered previously. This paper explores the idea that hx of cocaine use produces both an over-reliance on habit- based decision making and an under-reliance on model-based decision making. 2 groups of animals trained: 1 sucrose self-admin, 1 cocaine self-admin x2wks. Rewards received when lever pressed but with 40s mandatory interval. Cocaine rats titrated their dose (too much elevated hr which was not good), they did not press. Sucrose rats press lever furiously the level as much though they were high the entire time they were in the cage.
