PSYT 301 Lecture Notes - Lecture 10: Peripheral Artery Disease, Decode Genetics, Nicotine
24 Feb 2016
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Genetic factors: current candidate genes under investigation: polymorphisms of dat, 5ht, dopamine, as well as cyp450 enzymes. Might be genetic factors that influence why people cannot quit, or who smokes more than others. Decode genetics - nature, april 2008: a variant associated with nicotine dependence, lung cancer, and peripheral arterial disease. A common variant in the nachr on chromosome 15q24 was associated with smoking quantity tobacco dependence and the risk of lung cancer and arterial disease. However the results on chromosome 15 were not completely replicated in subsequent studies. Half of psychology studies fais reproducibility test, only 39 of the 100 major studies were found to not be replicated. Fagerstrom nicotine dependence test, 5 questions, higher the score the more nicotine dependent someone is. Nicotine dependence and alcohol dependence were most often comorbid. Alpha 3, 4, 5, beta 4,6 -- review found that multiple different genes.
