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BIOCHEM 2EE3 (153)
Lecture

Biochemistry 2EE3 Lecture 23.docx

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Department
Biochemistry
Course
BIOCHEM 2EE3
Professor
Boris Zhorov
Semester
Winter

Description
Biochemistry 2EE3 Lecture 23 • • • Protons power the motor to provide mechanical energy • Cannot move through membrane • This power synthesizesATP • • To minimize friction, “grease” is present in terms of hydrophobic residues (fat) to minimize heat loss • Hydrophobic regions are white, hydrophilic are red and orange • When motor rotates, friction is reduced dramatically • ATPase is largest consumer ofATP in body, related to mechanism ofATP synthesis because needs energy to work • ATPase restores gradient after action potentials • • Proton provides energy by moving according to concentration membrane (intermembrane space to mitochondrial matrix) • • Binding ofADP and Pi loosely (important not covalently bound yet) • Changes orientation 120 degrees, Lbinding site becomes T binding site and squeezes the two together despite repulsion • Chemical bond formed to createATP • High amount of energy conserved in bond due to high repulsion • Proton provides energy, binding site loosens,ATP released • Motor is reset • • Inner membrane impermeable to protons unless in form ofATP • ExcessATP stops rotation ofATP synthase, protons can’t go back • When concentration is high of protons, electron transport chain is in
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