BIOCHEM 4M03 Lecture Notes - Lecture 21: Mast Cell Stabilizer, White Adipose Tissue, Ketotifen
19 Mar 2017
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Biochem 4m04 lecture 21 journal club: interplay between macrophages & mast cells in metabolic disease. Leptin deficiency shifts mast cells toward anti-inflammatory actions and protects mice from obesity and diabetes by polarizing m2 macrophages. White adipose tissue low-grade inflammation in tph1+/+ and tph-/- Decrease in inflammatory markers these markers are all associated with proinflammation. Cd69 macrophage specific cell surface glycoprotein. Nutrient excess in interplay of these 3 cells: mast cells, macrophages, eosinophils. Tph1 is rate limiting enzyme of serotonin specifically in periphery nervous system. Cytokines: substances secreted by immune cells that have effects on other cells (ex. interleukins) Both eosinophils and m2 macrophages can modulate shift of pdgfr-alpha mesenchymal cells. Eosinophils go to il-4 (interleukin-4induce mesenchymal cells) Increase in body weight in mice, increase cd68 expression, increase bmi. Increase in average adipocyte area with nutrition excess, increase in f4/80 (main histology marker) Obesity is associated with macrophage accumulation in adipose tissue. M1: genes associated inos, tnfalpha, il6.
