BIOCHEM 2EE3 Lecture Notes - Lecture 5: Chromosome, Dna Ligase, Ribonuclease H

• School: McMaster University
• Department: Biochemistry
• Course: BIOCHEM 2EE3
• Professor: Russell Bishop

Document Summary

When copied, one of the 2 dna strands is conserved in each progeny. Dna replication proceeds after dna double helix is unwound and each parent stran new strand called the daughter strand. One of two daughter duplexes is the parental duplex while the other is de no. Parental material is scattered through structures of daughter duplexes. Proceeds in both directions from same starting point (the origin of replication. Dna is wound and the two replications are started - which continue down th directions towards terminus strand acts as the template for a e novo tion wn the chromosome in opposite. In an ideal world we"d need two dnaps, dnap 1 and dnap 2. Dnap only adds nucleotides to the free 3"oh end of a growing polynucleotide. Additionally it requires a pre-existing 3"end and cannot initiate replication de. Leading strand synthesis (1) unwind dna using dna helicase. Separates the double helix into it"s two antiparallel strands.