BIOCHEM 3H03 Lecture Notes - Lecture 11: Aldosterone, Immunoglobulin Light Chain, Lipoprotein

• School: McMaster University
• Department: Biochemistry
• Course: BIOCHEM 3H03
• Professor: Stephen Hill

Document Summary

Can be roughly divided into: acute kidney injury potentially reversible, chronic kidney disease develops over many years. The common end point of many causes. Irreversible dialysis or transplantation may be required in end stage renal. Rapid loss of renal function (hours to days) Retention of urea, creatinine, h+, and other metabolites (normally get rid of these through kidney) May or may not show oliguria (reduced urine output, < Damage to kidneys unable to get rid of the things you want to get rid of, and unable to save those you want. May be partly an adaptive mechanism to conserve water and na to try to maintain ecf volume. If not corrected may lead to intrinsic damage to kidney: treatment support ecf volume, improve renal perfusion, correct underlying cause; may require haemodialysis, intrinsic damage to kidney. Nephrotoxic drugs, x-ray contrast medium, specific renal diseases, intra-renal obstruction (mb, igg light chains) Hemoglobin too large to get filtered through (tetramer)