BIOCHEM 3H03 Lecture 7: BIOCHEM 3H03 LECTURE 7

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Biochem 3h03 lecture 7: chapter 9, thyroid gland lomoar cpsd| 2151316. T4 is converted in peripheral cells to t3 o. Crossescellmembranesandbindstonuclearreceptors o involved in mrna and protein o lag time can be hours to days for full effect o. Fetal brain and skeletal development fetus depends mostly of fetal hormone, some maternal t4 can cross placenta. Lack of maternal iodine in diet can lead to low hormone levels in mother and fetus. Increase o2 use and heat production= increases atp production in almost all tissues. Increased cardiac motility, heart rate and cardiac output. Sympathetic= increase beta adrenergic receptors in muscle, adipose and lymphocytes (increased sensitivity to catecholeamines) Increased gi motility: kinds of thyroid hormones o trh. Hypothalamic tripeptide whose synthesis and secretion is controlled by negative feedback from t4 and t4 and by negative feedback from tsh via a short loop. Use is to assess the status of pituitary hyposecretion of.

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