BIOCHEM 4M03 Lecture Notes - Lecture 25: Insulin-Like Growth Factor 2, Glycogenesis, Birth Weight

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Biochem 4m03 lecture 25 - early life metabolic regulation iii. Don"t confuse placental lactogen with lactate (sometihg like that) Regulators of fetal growth: genetics, nutrition, endocrine fetus. Pretty slow in first bit then rises rapidly then tends to plateau off at end: fetus now huge at end so providing its own constraint. Draw this graph (above right) when she asks why birth weight is not good reflection of growth pattern: describe 3 babies grow at different rates that end up at same birth weight. Because it"s anabolic, all enzymes favour deposition (energy storage) Fetal enzymes favour: glycogenesis glu glycogen: glucose is preferred fuel of fetus, lactate is number two. Lipogenesis fatty acid synthetase pathway adipose: de novo synthesis from acetyl coa. Protein synthesis: most essential and non-essential amino acids are transported across placenta. Fetal glucose utilization rates > neonate or adult. Placenta has high capacity to uptake and transport glucose: glut1 and 3, rapid transport, gradient, to fetus.

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