BIOCHEM 4M03 Lecture Notes - Lecture 33: Trophoblast, Skeletal Muscle, Insulin-Like Growth Factor 2
16 Apr 2018
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Insufficient growth of the vessels that transport nutrients, oxygen: placental transport and abnormal fetal growth, reduction in maternal cardiovascular fn. Reduced blood flow: abnormal villi development(maternal side, villi are the trees that branch into get blood flow. In humans we have a hemochorial placenta, we need direct contact between fetal tissue and maternal blood vessel: poor oxygenation, maternal smoking can limit oxygen to fetus. If pla(cid:272)e(cid:374)ta does(cid:374)"t gro(cid:449) proper, (cid:374)either (cid:449)ill fetus: both fetus and placenta produce igfs, cut through the placenta, measured the thickness, thicker barrier. If you k/o igf2, the exchange barrier becomes thicker, deceasing diffusion capacity. Exam qn: pre-conception bmi, maternal weight gain is influenced by bmi. If less than 18. 5, total weight gain is higher than all other pre-pregnancy. Bmis: 1/5 (cid:449)o(cid:373)e(cid:374) do(cid:374)"t get e(cid:374)ough (cid:449)eight gai(cid:374) If weight gain is low, probability of a small baby is very high: vice versa, for large babies.
