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Lecture

APOPTOSIS

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Department
Biology
Course
BIOLOGY 2D03
Professor
Laura Parker
Semester
Fall

Description
APOPTOSIS – neat, organized form of cell death (as opposed to necrosis) Functions – harmful cells (autoimmune) defective/excess/obsolete virally infected exposed to chemotherapeutic drugs 2 phases: LATENT: variable in length; no morphological changes point of no return EXECUTION: very rapid; end in cell death INTRACELLULAR PROTEOLYTIC CASCADE – CASPASES PROcaspases activated by cleavage INITIATORS – autocleaved with appropriate scaffolding activate downstream EFFECTOR caspases contain PRODOMAINS (DED, CARD) that recruit w/ scaffolding Initiator Activation: (only tip of iceberg) extrinsic – signal from outside cell (FAS LIGAND) intrinsic – within cell (DNA damage, cytC) ADAPTER proteins – activat
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