BIOLOGY 1A03 Lecture Notes - Lecture 2: Cystic Fibrosis, Wheeze, Goblet Cell

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Alastair Tracey Rosa Da Silva

Document Summary

The most common fatal genetic disease (1/3,600 children born in canada) Many effects on the body, but mostly affects digestion and lungs. With chronic persistence and bacterial infections, destruction of lungs leads to most prevalent cause of death. (current life expectancy ~ 40 years) Goblet cells secrete mucus which traps any dust particles and bacteria. Cilia motility and cilia generated flow push mucus up and out the trache. Cystic fibrosis transmembrane conductance regulator (cftr) gene is expressed on the long arm of chromosome 7.