BIOLOGY 1A03 Lecture 6: Lecture 6

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Rosa Da Silva

Document Summary

Mucus clearance is essential for respiratory health: globet cells: secrete mucus which traps any dust particle and bacteria. !1: ciliated cells: tiny hairs that move mucus along airways (they beat and move in aqueous environment, airway surface liquid: in healthy lung aqueous solution that allows for ciliates to move/beat rhythmically to move the mucus (mucociliary transport) A cystic fibrosis milestone: before the human genome project they took two populations, one with cystic. They compared their chromosomes and found that chromosome 7 differed: the cftr gene was discovered in 1989 at the sick kids hospital (toronto) Cftr channels are important for airway clearance: mucus transport is the primary lung defence mechanism and it fails in patients with cystic brosis. Mutations of cftr gene lead to cystic brosis: over 1. 900 disease-associated mutations, the deletion of one amino cid (phenylalanine) at amino acid reside 508 is the most common mutation that accounts for over 2/3 cystic brosis cases.