BIOTECH 3PM3 Lecture Notes - Lecture 13: Isosorbide Mononitrate, Isosorbide Dinitrate, Coronary Artery Disease
4 Dec 2017
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Mcmaster university biotech 3pm3 pharmacology week 13. Angina pain that arises in the chest from lack of oxygen in the blood. Supply essential nutrients and oxygen to the heart by pumping blood from the left ventricle to the heart, directly. These arteries are particularly prone to fatty deposits called plaques. Ischemia is a decrease in blood flow (leads to hypoxia) Hypoxia is a decrease in oxygen levels (anemia) A coronary artery disease that causes chest pain due to cardiac ischemia. If one or more arteries are totally blocked, then that would result in a myocardial infarction (heart attack) Reducing the frequency and severity of anginal attack. Exertional caused by exercise, overexertion or stress (always predictable) Variant or prinzmetal caused by vasospasm of coronary arteries. Unstable caused by almost completely blocked coronary arteries (most dangerous) Nondrug treatment include diet, exercise, elimination of smoking, and weight control. For pharmacotherapies, the three classes are: nitrates, beta-adrenergic blockers, calcium channel blockers.
