HTHSCI 1H06 Lecture 10: Immune Regulation (online)
4 Apr 2018
School
Department
Course
Professor
Document Summary
Influenza infection: rna virus that infects the respiratory tract. Common symptoms: productive cough, mucous, cilia, expulsive reflexes, generalized aches, fever. Resident defences: cells detect influenza with tlr3 (dsrna) & other prrs, epithelial cells and macrophages produce interferons and cytokines/chemokines, dendritic cells mature. Process and present influenza peptides in: mhc 1 (if infected themselves, mhc ii (after phagocytosing infected material) In the lymph node, activated dendritic cells present influenza virus peptides in mhc to many native t cells. When a t cell with a tcr that"s specific for influenza virus finds that dendritic cell, they couple, and the t cell becomes activated. The t cell divides rapidly and differentiates to become effector. An activated t cell runs into many b cells in the lymph node. When an activated influenza-specific t cell runs into an influenza-specific b cell, it provides help and activates the b.
