HTHSCI 1LL3 Lecture Notes - Lecture 9: Eukaryotic Dna Replication, Semiconservative Replication, Dna Replication
24 Sep 2018
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Mitosis: dna replication, creates two sets, one for each of the daughter cells, mitosis, two diploid cells, has two sets of chromosomes. Replication is semi-conservative: the dna strand separates and the new strand is built directly off the original strand by building complementary bases onto it. 02/07/17: bacteria uses the same nucleotides as our eukaryotic cells. Helix unwinding: dna has to be opened up so both sides get copied. Topoisomerase: a topoisomerase is an enzyme that can break and rejoin the strands to relieve tension from twisting, clips the phosphodiester bond, allowing it to swing free and unravel. Leading and lagging strands: are removed and replaced with dna: okazaki fragments= the pieces of the read lagging strand, ligase is the enzyme that joins the ends of the pieces together, pulls the fragments together. In addition to mistakes made when replicating dna, environmental agents can introduce mutations: without repair mechanisms mutations would accumulate, severely shortening our lives, combat the environmental questions.
