HTHSCI 2H03 Lecture Notes - Lecture 17: Hypotension, Cerebral Cortex, Antiemetic

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 2H03
• Professor: Kirsten Culver

Document Summary

Drugs for psychoses & degenerative diseases of the cns. Dopaminergic system: dopamine (da) is inhibitory & excitatory, precursor of norepinephrine. Important brain areas: nigrostriatal tract (substantia nigra striatum) Important area for motor control; can be affected by antipsychotic drugs. Not a targeted treatment area for psychosis, however: mesolimbic tract (vta limbic system, mesocortical tract (vta prefrontal cortex, tuberoinfundibular tract (hypothalamus pituitary) Does not play a major role in psychosis. D1-like dopamine receptors: d1, d5 = gs protein associated. D2-like dopamine receptors: d2, d3, d4 = gi protein associated. Involved in motor control, reward & motivation: increased activity in psychosis (i. e. schizophrenia, decreased activity in neurodegenerative diseases (i. e. parki(cid:374)so(cid:374)"s) Chronic psychiatric disorder affecting 1-2% of the population. Chara(cid:272)terized (cid:271)y a (cid:272)o(cid:373)(cid:271)i(cid:374)atio(cid:374) of positi(cid:448)e & (cid:374)egati(cid:448)e sy(cid:373)pto(cid:373)s : positive- client responds in an exaggerated response to stimuli, negative- less motivation, reward, capacity for pleasure manifest first. Illusions = misinterpreting stimuli (i. e. thinking an iv line is a snake)