HTHSCI 2H03 Lecture Notes - Lecture 10: Indigestion, Nasal Congestion, Linagliptin
10 Apr 2018
School
Department
Course
Professor
Document Summary
Dipeptidyl peptidase-4 inhibitor (dpp-4) sitagliptin(januvia) lomoar cpsd| 2151316. Hth sci 2h03 pharmacology of the endocrine system 2: drugs for the management of. Impedes intestinal re-absorption of bile - lowers ldl lowered ldl has positive effects on insulin sensitivity. Side effects include nausea, orthostasis, and nasal congestion. Amplifies incretin pathway activation by inhibiting the enzymatic breakdown of. Incretins are hormones secreted by the intestine following a meal when glucose is elevated which signal the pancreas to increase insulin secretion and the liver to stop glucose production. Glp-1 also slows glucose absorption in the intestine. Diabetic patients are unable to secrete incretins in adequate amounts. The normal function of dpp-4 is to break down incretins such as glp-1 and gip. Thus, dpp-4 inhibitors reduce the destruction of incretins, increases incretin levels, increases insulin secretion and decrease/slow glucose absorption. Lowers a1c by <2. 0% study results: doses of 100 mg/day or higher achieved.
