HTHSCI 2H03 Lecture Notes - Lecture 2: London Underground S7 And S8 Stock, Loading Dose, Acid Dissociation Constant
18 Sep 2018
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Acid a drug that dissociates in water to produce h (proton donor) Base a drug that accepts h in water (proton acceptor) Only drugs in their non-ionized / neutral form can pass through plasma membranes and become absorbed. Only fat soluble drugs can pass through. Intestines = basic (ph of 8) pka = the strength of an acid, the ph at which the acid"s concentration in its ionized form is equal to the acids concentration in its non-ionized form. 1 / fr = 1 + [a ] / [ha] Loading dose a dose of drug administered to prime the bloodstream with a plasma drug level sufficient to quickly induce a therapeutic effect purpose: to produce a rapid and effective therapeutic response. Clearance volume of plasma completely cleared of a drug per unit of time depends on the half life of a drug to determine how fast it will clear.
