HTHSCI 2H03 Lecture Notes - Lecture 7: Central Nervous System Depression, Area Postrema, Myelin

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 2H03
• Professor: Kirsten Culver

Document Summary

Loss of sensation to a speci c area of the body without the loss of consciousness. Most local anesthetics exert their effects through a common mechanism of action. Block the movement of sodium through the channels. To improve duration of action, local anesthetics are sometimes co-administered with epinephrine. Has a localized effect just like the anesthesia. To prolong duration of action of the local anesthetic. Rapidly metabolized in the bloodstream by esterase. These amides remain in a fat soluble state. Better at penetrating in the membranes in the myelin sheath. Not all nerves are equally susceptible to local anesthesia. C bres: visceral pain (dull, aching pain) More than 60% of canadian women will choose some form of regional anesthesia during labour. Epidural or intrathecal (spinal) injection of local anesthesia. Blocking all sensory responses (no pressure or contractions) Motor responses are also blocked, so the woman cannot really move.