HTHSCI 2H03 Lecture Notes - Lecture 10: Posttraumatic Stress Disorder, Suicidal Ideation, Monoamine Oxidase Inhibitor
29 Apr 2016
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Document Summary
Pathogenesis of mental illness may involve one ore more of the following: Neurons originating from the locus ceruleus (back of the brain) project to limbic system (neocortex, amygdala, hippocampus, cerebellum) Maintains emotional tone (mood, arousal ability to engage, wakefulness and reward) Things that previously made them happy don"t anymore. Increased noradrenergic activity associated with manic symptoms observed in bipolar disorder. Everything is exciting, everything makes them feel good. Important in pain and perception of pain. Neurons originating in raphe nuclei project to the limbic system and cerebral cortex (co- localized with ne system) Many receptor classes: 5-ht1 to 5-ht7 with subtypes for each. Maintains sleep-wake cycle, emotional tone and sensory perceptions (e. g. pain) Decreased serotonergic activity associated with depression and anxiety. Inability to derive pleasure or experience interest in most activities. Lack of interest in appearance, sex, leisure activities. Presents 2 weeks to 6 months after childbirth. Characterized by alternating periods of depression and mania.
