PSYCH 2AP3 Lecture Notes - Lecture 18: Generalized Anxiety Disorder, Corticotropin-Releasing Hormone Receptor 1, Pituitary Gland
17 Feb 2017
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Document Summary
Hpa function altered in anxiety (and depression) Young stressed macaques show anxiety -, depression like symptoms as adults, plus changes in hpa. Early experiences shape hpa reactivity, passed on epigenetically. Mice without crh-r1 gene for crh receptors = reduced anxiety; mice without crh-r2 gene = increased anxiety. Increased epinephrine, reduced inhibitory gaba in anxiety disorder. Monoamine serotonin, norepinephrine drugs targeting these alleviate anxiety. Social phobia also shows dysfunction in serotonin, dopamine symptoms. Possibility; the symptoms are the cause of changes in neurotransmitter activity. Parents with anxiety = children 3-5 times more likely to have anxiety. 41% mz concordance rate for anxiety reaction, 4% dz. No one gene responsible for more than 5% of variability in anxiety. Mice lacking 5 ht1a (auto) receptor show increased anxiety. Delay expression of 5 ht1a receptor for 4 weeks = adults with increased. Human studies suggest link between 5 ht1a receptor and anxiety, depression. Anxiety and depression are comorbid with each other.
