PSYCH 2NF3 Lecture Notes - Lecture 26: Neurodegeneration, Basal Ganglia, Huntingtin
22 Jan 2019
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**basal ganglia importance*: size of ventricles: in normal bg, regular amount of brain tissue covering the ventricles in hd, very small amount of tissue surrounding the ventricles of the. Bg the bg of the human brain: the brain of a person with hd has bigger openings due to the death of nerve cells in that region. Most people develop huntington"s disease between 30-54 years old but it can manifest as early as 4 years old and as late as 80 years. Huntington"s disease is clinically characterized by a triad of motor, cognitive and psychiatric symptoms. Cognitive features are characterized initially by loss of speed and flexibility in thinking, but later become more global. Psychiatric features may include: depression (most common), mania, obsessive-compulsive disorder, irritability, anxiety, agitation, impulsivity, apathy, and social withdrawal. Projection from the substantia nigra to the basal ganglia dies.
