ANAT 215 Lecture Notes - Lecture 3: Lamina Lucida, Basal Lamina, Epithelium

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tealmoose406

20 Oct 2014

School

Queen's University

Department

Anatomy and Cell Biology

Course

ANAT 215

Professor

Leslie W Mac Kenzie

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Document Summary

Tissues are collections of specialized cells and cell products that perform a specific function. Organs are formed by two or more tissues that are united in patterns to perform a series of specific functions. Systems are formed by an interacting group of organs that performs one or more specific functions essential for the well being of the organism. Epithelium is a tissue composed of closely apposed cells with very little or no intervening intercellular substance so closely packed there is no apparent space, sheet of cell cover, lines all of blood vessels. Characteristics: cellularity: adjacent cells are joined by specialized junctions polarity: an epithelial cells has an exposed (apical) surface that faces the exterior of the body or internal space, and a basal surface where it is attached the underlying tissue. Types of epithelium: covering epithelium tissue composed of cells organized in layers that covers the surface (focus of anat 215 ) glandular epithelium.

Related Questions

Hybridomas are the useful result of a fusion between _______________ and _________________ to obtain hybrid cells that can proliferate and produce _________________ against specific ________________.

	myeloma cells; B lymphocytes; monoclonal antibodies; epitopes
	myeloma cells; T lymphocytes; polyclonal antibodies; antigen
	T lymphocytes; B lymphocytes; monoclonal antibodies; antigen
	T lymphocytes; B lymphocytes; polyclonal antibodies; epitopes

With respect to mammalian cell culture, which of the following statements is true?

	Media used for cell growth contain proteases and a divalent cation chelator to help cells adhere to the surface.
	During the establishment of a cell line, senescence is the last stage of the cell's life.
	Rodent cells cultures undergo spontaneous transformation with similar frequency to human cell cultures.
	Embryonic cell lines do not undergo senescence nor do they have a finite life span.

Epithelial cells have distinct surfaces. Which of these surfaces tends to be involved in secreting proteins out of the cell and into the bloodstream?

	apical
	basal
	All of the answers are correct.
	lateral

Which of the following is NOT true of phospholipid bilayers?

		Phospholipid bilayers separate the cell from the exterior environment as well as from compartments within the cell.
		The interior of phospholipid bilayers is a highly hydrophobic environment.
		Membrane budding requires transient breakages in the bilayer membrane.
		The chemical properties of phospholipids lead to the spontaneous formation of bilayers.

Which of the following is true regarding membrane proteins?

		All peripheral membrane proteins contact the lipid bilayer by covalent attachment to the hydrophilic head groups on membrane lipids.
		Beta strands can assemble into a membrane-spanning barrel structure.
		Lipid-anchored membrane proteins always face the cell exterior.
		A protein with six hydrophobic helices is most likely a lipid-anchored membrane protein.

Which of the following statements is NOT true?

		The three types of lipid anchors responsible for tethering proteins to the bilayer are acylation, prenylation, and ubiquitinylation.
		Movement of lipids from the cytoplasmic to the exoplasmic leaflet of the membrane bilayer requires specialized transport proteins called flippases.
		Glycoproteins are the basis for blood type compatibility between donor and receiver.
		Glycoproteins are always oriented so that the carbohydrate moieties are exoplasmic.

Question 1.1. (TCO 1) Moving from the elbowtoward the wrist is an example of moving in a _____ direction.(Points : 4)

distal
lateral
medial
proximal

Question 2.2. (TCO 1) The left and rightpleural cavities are part of this cavity. (Points : 4)

Abdominal
Pelvic
Dorsal
Thoracic

Question 3.3. (TCO 1) The _____ separatesanterior and posterior portions of the body. (Points : 4)

transverse plane
sagittal plane
parasagittal plane
frontal plane

Question 4.4. (TCO 1) A parasagittal plane_____. (Points : 4)

separates superior andinferior portions of the body
separates right and leftportions of the body
misses the midline,separating right and left portions of unequal size
separates anterior andposterior portions of the body

Question 5.5. (TCO 1) Which of the followingterms is not used to define the structure that separatesthe contents of a human cell from its surrounding medium? (Points :4)

Cell wall
Cell membrane
Plasma membrane
Plasmalemma

Question 6.6. (TCO 1) Approximately 60-80% ofa living cell is made up of _____. (Points : 4)

water
oxygen
lungs
potassium

Question 7.7. (TCO 2) Stratified cuboidalepithelia would be found _____. (Points : 4)

lining the urinarybladder
lining the ducts thatdrain sweat glands
lining kidneytubules
lining the stomach
at the surface of theskin

Question 8.8. (TCO 2) The layer of theepidermis that contains stem cells undergoing mitois is the _____.(Points : 4)

stratum corneum
stratum basale
stratum granulosum
stratum spinosum

Question 9.9. (TCO 2) The tissue that alwayshas a free surface exposed to the internal or external environmentis the _____. (Points : 4)

epithelial tissue
connective tissue
muscle tissue
neural tissue

Question 10.10. (TCO 2) The code to make aparticular protein is a gene located on a _____. (Points : 4)

tDNA molecule
RNA molecule
DNA molecule
tRNA molecule

Question 11.11. (TCO 2) The lipid bilyaer ofthe plasma membrane is constructed largely of _____ with smalleramounts of cholesterol and glycolipids. (Points : 4)

cholesterol
neutral fats
phospholipids
fat-soluble vitamins

Question 12.12. (TCO 2) A group of similarcells and their intercellular substances specialized to perform aspecific function is a(n) _____. (Points : 4)

cell
tissue
organ
atom

Question 13.13. (TCO 3) The _____ of sweat isproduced by the action of bacteria feeding on the sweat. (Points :4)

color
odor
salt
nitrates

Question 14.14. (TCO 3) An acquired skindisease resulting in irregular patches of skin of various sizes andcompletely lacking pigmentation is known as _____. (Points :4)

albinism
impetigo
vitiligo
ringworm

Question 15.15. (TCO 3) Squamous cellcarcinoma arises from this layer of the skin. (Points : 4)

Stratum spinosum
Stratum corneum
Stratum granulosum
Stratum basale

Question 16.16. (TCO 3) The primary purpose ofsensible perspiration is _____. (Points : 4)

to heat internal bodyorgans
to heat the skin
for evaporativecooling
to get rid of bodywaste
to elevate bodytemperature

Question 17.17. (TCO 3) Sweating is anevaporation process that _____ the body. (Points : 4)

cools
heats
has no effect on
dries the body

Question 18.18. (TCO 3) When the _____ musclecontracts, it causes the hair to stand on its end. (Points :4)

vellus
terminal hair
rrrector pili
arrector pili

Question 19.19. (TCO 4) The formation of redand white blood cells by the red bone marrow is known as _____.(Points : 4)

hematopoiesis
periostesis
mastication
cartilage

Question 20.20. (TCO 4) Yellow bone marrowcontains a large percentage of _____. (Points : 4)

fat.
blood-formingclots.
elastic tissue.
Sharpey's fibers.

Question 21.21. (TCO4) The shaft of a longbone is called the _____. (Points : 4)

physis
epiphysis
diaphysis
metaphysis
lamella

Question 22.22. (TCO 4) The boundaries betweenskull bones and between immovable joints are _____. (Points :4)

foramina
fontanels
lacunae
sutures

Question 23.23. (TCO 4) The _____ is theexpanded prominence of the upper hip bone. (Points : 4)

sacrum
coccyx
pubis
iliac crest

Question 24.24. (TCO 4) The _____ is afibrovascular membrane that covers a bone. (Points : 4)

endosteum
yellow bone marrow
periosteum
compact bone marrow

Question 25.25. (TCO 5) The bones that formthe wrist are the _____. (Points : 4)

carpals
tarsals
metatarsals
phalanges

Question 26.26. (TCO 5) The following isnot
a structure found on the ishium. (Points : 4)

Superior ramus
Inferior ramus
Lesser sciaticnotch
Superior body

Question 27.27. (TCO 5) The side walls of thevertebral foramen are formed by the _____. (Points : 4)

centrum of thevertebrae
spinous process
pedicles
laminae

Question 28.28. (TCO 5) The largest facialbones are the _____. (Points : 4)

palatine bones
nasal bones
lacrimal bones
maxillary bones

Question 29.29. (TCO 5) The bone in directcontact with the first metatarsal (big toe) is the _____. (Points :4)

medial cuneiform
lateral cuneiform
cuboid
calcaneus

Question 30.30. (TCO 5) The antebrachium iscomposed of which of the following two bones? (Points : 4)

The radius and theulna
The humerus and theclavicle
The scapula and theclavicle
The humerus and theradius

Question 31.31. (TCO 6) A joint united bydense fibrocartilaginous tissue that permits a slight degree ofmovement is a _____. (Points : 4)

suture
syndesmosis
symphysis
gomphosis

Question 32.32. (TCO 6) Articular cartilagefound at the ends of the long bones serve to _____. (Points :4)

attach tendons
produce red blood cells(hemopoiesis)
provide a smooth surfaceat the ends of synovial joints
form the synovialmembrane

Question 33.33. (TCO 6) The cruciate ligamentsof the knee _____. (Points : 4)

tend to run parallel toone another
also are calledcollateral ligaments
prevent hyperextension ofthe knee
assist in defining therange of motion of the leg

Question 34.34. (TCO 6) Menisci refer to_____. (Points : 4)

cavities lined withcartilage
small sacs containingsynovial fluid
semilunar cartilagepads
tendon sheaths

Question 35.35. (TCO 6) Synovial fluid ispresent in joint cavities of freely movable joints. Which of thefollowing statements is true about this fluid? (Points : 4)

It contains onlyenzymes.
It contains lacticacid.
It contains hyaluronicacid.
It contains hydrochloricacid.

amaranthworm158

1. Kinesin-1 motors can move long distances on microtubule tracks without dissociating. By contrast, myosin II motors in skeletal muscle take only one or a few steps before letting go. What is most likely the difference between these two motors that allow two different types of movement?

A. Differences in length of the stalk of each respective motor allow for differences in step size

B. Differences in ATP versus GTP hydrolysis alter the motor head movement along filaments

C. Actin filaments are smaller in diameter and have less space for movement

D. Binding affinity of the Kinesin-1 motor head to microtubules is high, whereas binding affinity of the myosin II motor head to actin filaments is low

E. Microtubules are larger in diameter and have more space for movement

2. Dynamic instability causes microtubules either to grow or to shrink rapidly. What is the most likely reason for a microtubule to undergo rapid growth?

A. GTP hydrolysis exceeds the rate of heterodimer addition

B. GTP hydrolysis of alpha tubulin causes an outward bend in the heterodimer conformation

C. A low concentration of tubulin heterodimers are in solution

D. Heterodimer addition exceeds the rate of GTP hydrolysis

E. Increased trafficking of microtubule motor proteins favors stability

3. There are no known motor proteins that move on intermediate filaments (IFs). What property of intermediate filaments would most likely explain the lack of motor proteins?

A. Tissue specific expression of IFs prevent a single type of motor protein to evolve over time

B. Lateral bundling of IFs prevent motor movement

C. IFs are less dynamic than microtubules and actin filaments

D. IFs are unpolarized

E. IFs do not bind a nucleotide

4. You discover a mutation that results in less rapid hydrolysis of GTP by the beta-tubulin subunit. What would most likely occur?

A. There would be no change in filament assembly

B. There would be enhanced instability of the microtubule

C. There would be enhanced stability of the microtubule

D. Microtubules would not form

E. There would be enhanced treadmilling

5. Which of the following statements describes common features of cadherins and integrins?

A. They can link to microtubules using specific adapter proteins

B. They mediate heterophillic interactions

C. They achieve high binding affinity through clustering

D. They are responsible for interactions of a cell with the extracellular matrix

E. They are found in the apical plasma membrane of an epithelial cell

6. Intermediate filaments are uniquely non-polar and built by lateral bundling in five steps: 1) synthesis of an alpha-helical monomer, 2) formation of a coiled-coil dimer, 3) formation of a staggered tetramer of two coiled-coil dimers, 4) lateral association of 8 tetramers, and 5) addition of 8 tetramers to a growing filament. At what step is polarity lost?

A. Step 1

B. Step 2

C. Step 3

D. Step 4

E. Step 5

7. Collagenase is an enzyme that breaks peptide bonds in collagen to help destroy extracellular structures. What would be the most likely reason to use collagenase in a cell biology laboratory?

A. Disrupt cadherin interaction with the extracellular matrix

B. Disrupt cell-cell contacts to passage cells in cell culture

C. Dissociate epithelial cells from the underlying basement membrane to separate tissues

D. All of the answers are likely uses for collagenase

E. Lyse cells to expose intracellular proteins and organelles

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ANAT 215 Lecture Notes - Lecture 3: Lamina Lucida, Basal Lamina, Epithelium

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