BIOL 334 Lecture Notes - Lecture 4: Proteolysis, Protein Structure, Microrna
25 Apr 2018
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Mechanism of catabolism vs anabolism both need to operate independently. Three roles of catabolism: atp, low molecular weight building blocks, reduce power. Issue #2: wasteful hydrolysis of atp from e2 and e3 cycle: solved by temporal separation, same regulatory signalling have opposite effects for the two different. What are anaplerotic pathways: a pathway used to replenish cyclic pathway intermediates that have been depleted for biosynthesis, example: tricarboxylic cycle (tca, used as an anabolic precursor and fuel is provided by anaplerotic carboxylases. + atp > oxaloacetate + adp + pi) Mc = rate of movement (flux) of metabolites through a pathway must be controlled so that flux is only as great as required: rate of control and flux achieved through regulating a few pathway enz. Two distinct types of mechanisms of mc: coarse control, fine control. By rates of enz synthesis vs degradation. Consists of 6 fine controls (fc: [s, ph, allosteric effectors, reversible covalent or post-
