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Lecture

HLTH 101 Lecture Notes - Severe Combined Immunodeficiency, Cystic Fibrosis, Opportunistic Infection


Department
Health Studies
Course Code
HLTH 101
Professor
Glenn Ward

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TOPIC 6. INTERNAL ECOLOGY: INDIVIDUAL
FACTORS POTENTIALLY ASSOCIATED WITH
INFECTIOUS DISEASE RISK
1/ IMMUNOCOMPETENCE
Immunosuppression
-decrease in hosts natural ability to resist microbes
-results in:
a) opportunistic infection
-endogenous microbe causes disease
b) susceptibility to new infection
c) disease from attenuated virus in vaccine. Ie. Sabin poliovaccine
Causes of immunosuppression:
i. Inherited Diseases
-ie. Severe Combined Immunodeficiency (boy in bubble)
-often x-linked
-others: DiGeorge disease can’t make enough T-cells
Cystic Fibrosis inability to clear impurities
ii. Aging
-decrease in immune response (especially T-cells)
-often take anti-inflammatory drugs
-decrease in effective immunizations
iii. Prematurity
-only a few weeks can make a difference as the immune
system develops late.
-results in underdeveloped immune system
Ie. increased risk in group B streptocci disease
iv. Radiation Exposure
-causes neutropenia (reduced neutrophils (ie. white blood
cells) which destroy microbes
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