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HLTH 101 (129)
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Lecture

Health 101 Topic 6 Internal Ecology: Individual Factors Potentially Associated with Infectious Disease Risk (abstract) 1/ IMMUNOCOMPETENCE Immunosuppression -decrease in hosts natural ability to resist microbes -results in: a) opportunistic in

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Department
Health Studies
Course
HLTH 101
Professor
Glenn Ward
Semester
Fall

Description
TOPIC 6. INTERNAL ECOLOGY: INDIVIDUAL FACTORS POTENTIALLY ASSOCIATED WITH INFECTIOUS DISEASE RISK 1/ IMMUNOCOMPETENCE Immunosuppression -decrease in hosts natural ability to resist microbes -results in: a) opportunistic infection -endogenous microbe causes disease b) susceptibility to new infection c) disease from attenuated virus in vaccine. Ie. Sabin poliovaccine Causes of immunosuppression: i. Inherited Diseases -ie. Severe Combined Immunodeficiency (boy in bubble) -often x-linked -others: DiGeorge disease – can’t make enough T-cells Cystic Fibrosis – inability to clear impurities ii. Aging -decrease in immune response (especially T-cells) -often take anti-inflammatory drugs -decrease in effective immunizations iii. Prematurity -only a few weeks can make a difference as the immune system develops late. -results in underdeveloped immune system Ie. increased risk in group B streptocci disease iv. Radiation Exposure -causes neutropenia (reduced neutrophils (ie. white blood cells) which destroy microbes -results in increased opportunity for infection v. Pregnancy -still unclear but thought to be due to methological problems -suppression of immune system to not reject baby -generally few problems if well nourished, but increased risk if not -39 weeks into pregnancy = drop in interleukin response (response to activate immune system) vi. Malnutrition - Most common cause globally - Less
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