MICR 360 Lecture Notes - Lecture 10: Immunoglobulin G, Oligomer, Immunoglobulin E

• School: Queen's University
• Department: Microbiology and Immunology
• Course: MICR 360
• Professor: Sameh Basta

Document Summary

In a non-lymphoid cell or a cell that is not going to be a b cell. In cells that are committed to becoming b cells (found in bone marrow/stem cell) Gene segments in light & heavy chains: the fact that 1011 (100 billion) different antibodies can be made. The capacity to make these antibodies is random: variable and constant domains in same chain, different classes of antibodies with same antigenic specificity awarded to dr. tonegawa for his discovery of. Recombining of gene segments to produce a functional variable-region sequence. Gene rearrangement happens with our antibody (immunoglobulin) & t-cell receptor genes. This is a result of somatic recombination (genetic gene rearrangement)! So basically, in the light chain, variable and joining gene segments code for the variable region of the l chain. Constant light chain gene segment codes for the constant region of the l chain. In the heavy chain v,d,j gene segments codes for the variable region of the heavy chain.