MICR 360 Lecture 16: MICR 360 6:2
22 Dec 2018
School
Department
Course
Professor
Document Summary
Endogenous ag presenting and presentation: cytosolic pathway papc. Dc, macro and b cells convert na ve t (has not seen ag) into effector t cells. Dc is the best convertor + constitutively express mhc ii + b7. Macro are act (thru cytokines) to express mhc ii + b7. B cells always express mhc ii but act to express b7. Non-professional apc= fibroblast, thymic epithelial, vascular endothelial, pancreatic beta, thyroid epithelial cells: convert protein ag to peptides and then display peptide-mhc complexes (ag processing, provide stimuli req for full responses of t cells (papcs) using mhc ii. Aka cr80/86, interacts w specific ligand on t cells to act them. 1 ag processing and presentation: endogenous or cytosolic. 2 t cell recognition of ag: peptides binds on and off until one has high enough affinity peptide displayed on mhc cleft and then bound by tcr. Cytosolic pathway: infected cell viral gene rep break down of viral proteins into frag via proteasome .
