MICR 360 Lecture 21: MICR 360 8:1
22 Dec 2018
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Document Summary
Tcr signaling initiated by cd45r interacting w cd22 act p56lck act nf-kb effector activites (cd8 for cytotoxic, cd4 for cytokine prod) Kinases= p proteins phosphatase: remove p from proteins. Addition or removal of p= act or inhibition of protein function. Lck: (p56lck) kinase on cd4/8, act by cd45r and p itams on cd3 chains and zeta chains. Phosphates act as docking sites for zap-70 kinase which is p by lck. Zap-70 p plcgamma which forms dag + incr ca. Incr ca act calcineurin phosphatase which dep and act nfat. 2: conact w costimulatory ligands, req for optimal t cell act + prolif, +ve costim=cd28 act t cells, -ve costim=ctla-4 turning t cell act off. 3: cytokines direct t cell prolif + diff into effector subtypes. Cd3: 2 epsilon, 1 delta, 1 gamma, zeta homodimer. Features: charges hold cd3 complex w tcr, dn signal until the tcr binds to ag presented in mhc.
