MICR 360 Lecture 12: MICRO 360 Igs
22 Dec 2018
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Document Summary
Bind to fcyr on diff cells act complement + adcc. Bacteria coated w complement + igg c3b binds cr1 and ab binds fc macro phagocytosis lysosomes kill. Antimicrobial is secretions, neut- prevent pathogen attachment to mucosa epith, siga-ag complex cleared via ciliated epith or peristalsis of gut. J chain made by b cell secretory component made from plgr + dimeric iga moving thru epithelial cell neut pathogens + toxins. Pentamer in serum (5 ab joined by disulphide bonds + j chain), monomer on b cell surface (bcr) 1st to appear in phylogeny, ontogeny + normal immune response. Confined to blood stream, good agglutinator (cross links ag w 10 binding sites) lacks hinge so ch2 has hinge like features. Confined to mature b cell memb w igm, no known bio effects. Larger, more rigid than igg, no hinge, binds fcer on mast + baso.
