PATH 310 Lecture Notes - Lecture 13: Deoxyribose, Cytogenetics, Cytosine

• School: Queen's University
• Department: Pathology and Molecular Medicine
• Course: PATH 310
• Professor: Christine Hough

Document Summary

Illinois bone marrow aspirate needle: pull out sample of bone marrow. Jamshidi bone marrow biopsy needle: take out bone marrow with a core. Aml diagnosis: bone marrow studies: bone marrow aspiration: removes a small amount of bone marrow through a needle put into a bone. The bone marrow is checked for problems with any of the blood cells made in the bone marrow. Cultures can also be done to look for infection: morphological features, flow cytometric analysis, cytogenic-fish analysis, molecular studies, bone marrow biopsy: removes bone with the marrow inside to look at under a microscope, morphology. Normal bone marrow histology: all cell types maturing, rbcs with nuclei, megakaryocytes: precursor to platelets. Karyotype analysis: this aml has recurrent genetic mutation, portion of chromosome 17 that is missing which is put on 15, translocation 15:17. Acute vs. chronis leukemia: chronic: won"t kill you quickly but can be fatal, acute: can die quickly if not treated but curable.