Class Notes (1,100,000)
CA (650,000)
Queen's (10,000)
PATH (40)
Lecture 12

PATH 310 Lecture 12: Acute Leukemia


Department
Pathology and Molecular Medicine
Course Code
PATH 310
Professor
Christine Hough
Lecture
12

This preview shows pages 1-3. to view the full 10 pages of the document.
Acute Leukemia
Stem Cells
Capable of self-renewal (although this is a rare event and stem cells are mainly
quiescent)
Are multipotent (i.e. can give rise to a remarkable number of daughter cells by
committing to successive differentiation steps, culminating in terminally-
differentiated, mature cells)
Hematopoietic Stem Cells
Hematopoietic stem cells (HSC) are found in the bone marrow, cord blood, and
in smaller numbers in the peripheral blood
Long-lived cells that give rise to all blood cells
Comprise approx. 1 per 108 bone marrow cells or about 11,000 to 22,000 per
person
Noral heatopoiesis is polloal
HSC contribute to the production of 1011 1012 new blood cells throughout the
body each day
Cancer: when there is no longer polyclonal, just monoclonal
Hematopoiesis
Hematopoiesis is the process of creating new blood cells in the body. All blood
cells start off as hematopoietic stem cells, and then specialize (differentiate) into
myeloid cells (erythrocytes, megakaryocytes, monocytes, neutrophils, basophils,
or eosinophils) or lymphoid cells (T-lymphocytes and B-lymphocytes).
In adults, primarily occurs in the bone marrow
HSC: hematopoietic stem cell
find more resources at oneclass.com
find more resources at oneclass.com

Only pages 1-3 are available for preview. Some parts have been intentionally blurred.

Leukemia: Acute vs. Chronic
Acute leukemia:
o hematopoietic cancer characterized by proliferation of immature cells
o usually progresses rapidly
o immediate treatment is usually required
Chronic leukemia:
o hematopoietic cancer characterized by proliferation of mature cells
o usually progresses slowly
o may be monitored for some time before treatment is initiated
find more resources at oneclass.com
find more resources at oneclass.com

Only pages 1-3 are available for preview. Some parts have been intentionally blurred.

Leukemia: 4 main types
Cell Type
Acute
Chroic
Lyphoid
Aute lpholasti leukeia ALL
Chroi lphoti leukeia CLL
Myeloid
Aute eloid leukeia AML
Chroi elogeous leukeia CML
Leukemias Disrupt Hematopoiesis
Acute Leukemia: Presentation
Pathology
Cliical Outcoe
Dereased red ells
Fatigue
Dereased platelets
Bleedig
Dereased hite ells
Ifetio
Ireased lasts
≥ 20%, 
defiitio
Leukostasis, tissue ifiltratio, orga failure, elarged lph
odes or splee
find more resources at oneclass.com
find more resources at oneclass.com
You're Reading a Preview

Unlock to view full version