PHAR 100 Lecture Notes - Lecture 13: Dopamine Agonist, Monoamine Transporter, Benzoylecgonine
12 Nov 2016
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Document Summary
It blocks the dopamine re uptake receptor such that excess da is in the synaptic cleft. Cocaine is absorbed at all sights of admission (ie intra nasal and intestine) and can freely cross the blood brain barrier and the placenta. Removed by enzymes in the liver and plasma leaving benzoylecgonine metabolite. Amphetamines are cns stimulants structurally similar to epinephine, norepinephrine and dopamine. Increase synaptic activity of dopamine and norepinephrine by interfering with vesicular monoamine transporter (breaks down dopamine). End result is increased neurotransmitter in the synaptic cleft leading to increased receptor activation and increased da and ne mediated effects. * high dose all of the above but also to bind to mao in da neurons to prevent da degradation in nerve terminal. Three features unique to cocaine: it is a powerful anesthetic, a vasoconstrictor and a powerful psychostimulant with reinforcing effects from the excess dopamine. Also produce euphoria, alertness and energy and decrease appetite.
