PHAR 100 Lecture Notes - Lecture 5: Methanol, Depressant, Cerebral Atrophy
17 Jun 2016
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Sugar + water + yeast = ethanol and carbon dioxide. The more distilled, the higher concentration in alcohol. 1742 consumption reached 19 million gallons were being consumed, so parliament shut it down and decided they needed regulation in place. Rapidly distributes throughout the body by passive diffusion. It distributes evenly thoughout the body and across the blood-brain barrier. Peak is usually obtained in 30 minutes. Pregnant women expose the baby to the same amount of alcohol and the same amount of time as the mother. 5% is excreted unchanged in breath, urine and sweat. Women have 50% less gastric metabolism due to lower levels of gastric alcohol dehydrogenase. Men have greater muscle-to-fat ratio so alcohol concentration is more diluted because larger vascular compartment. Women concentrate alcohol in plasma more than men (due to higher fat content) Various factors influence metabolism (alcohol flush aldh2 deficiency) o. They have higher concentration circulating than the average: asian descent have this deficiency more often.
