PHAR 340 Lecture Notes - Lecture 7: Circulatory System, Phospholipid, Bioavailability
23 Oct 2017
School
Department
Course
Professor
Document Summary
Metabolism (converting the drug into another form) Excretion (excreting the drug out of the body) The therapeutic window is between mec for adverse response and mec for desired response. In order for an oral drug to be effective, There are many ways that a drug can cross membranes. Drug passively passes into cell; no atp required, substance passively passes through membrane or through pores. Lipophilicity: refers to the ability of a chemical compound to dissolve in fats, oils, lipids, and non-polar solvents - important because the membrane is a lipid bilayer. Ionization of the drug ( if it is charged, this decreases lipophilicity) ; charged molecules are unable to pass through. Concentration gradient of the drug (from high [] to low [] ) These molecules go down concentration gradient (from a high concentration to a low concentration) not energy dependent! This process is limited by how available the carriers are.
