BLG 143 Lecture Notes - Lecture 4: Ribonucleoside, Deoxyribose, X-Ray Crystallography

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Nucleotide consists of: a phosphate group, a sugar, a nitrogenous base. Sugar: an organic compound with a carbonyl group and several hydroxyl groups. The phosphate group in a nucleotide is attached to the 5" (cid:272)a(cid:396)(cid:271)o(cid:374). Researchers concentrate on 2 types of nucleotides: ribonucleotides and deoxyribonucleotides. Ribonucleotides: the sugar is ribose, has an oh g(cid:396)oup (cid:271)o(cid:374)ded to the (cid:1006)" (cid:272)a(cid:396)(cid:271)o(cid:374). Deoxyribonucleotides: the sugar is deoxyribose, has a(cid:374) h (cid:271)o(cid:374)ded to the (cid:1006)" (cid:272)a(cid:396)(cid:271)o(cid:374). Laboratory simulations have shown that many sugars can be synthesized readily under conditions that mimic the prebiotic soup. Phosphodiester linkage the result of this condensation reaction. The phosphodieste(cid:396) li(cid:374)kage joi(cid:374)s the 5" (cid:272)a(cid:396)(cid:271)o(cid:374) o(cid:374) the (cid:396)i(cid:271)ose of o(cid:374)e (cid:374)u(cid:272)leotide to the (cid:1007)" (cid:272)a(cid:396)(cid:271)o(cid:374) o(cid:374) the (cid:396)i(cid:271)ose of the othe(cid:396). Ribonucleic acid: the polymer that is produced when the nucleotides involved contain the sugar ribose. Deoxyribonucleic acid (dna): the polymer that is produced when the nucleotides involved contain deoxyribose.

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